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Connective tissue responses to calcium hydroxide-based root canal medicaments.
P Nelson Filho1, L A Silva, M R Leonardo
1Department of Pediatric Dentistry, Ribeirão Preto Dental School, USP, Brazil.
International Endodontic Journal
|November 7, 1999
Summary
Calcium hydroxide pastes induce varying inflammatory responses in tissues. While all formulations showed some irritation, Calen paste demonstrated better biocompatibility and faster repair compared to others containing phenolic compounds.
Area of Science:
- Dental Materials Science
- Biocompatibility Studies
- Histopathology
Background:
- Calcium hydroxide is widely used in dental applications.
- Understanding the tissue response to different formulations is crucial for clinical success.
- Antiseptic agents can modify the biocompatibility of calcium hydroxide pastes.
Purpose of the Study:
- To evaluate the inflammatory tissue response to calcium hydroxide pastes.
- To compare the effects of paramonochlorophenol and camphor on this response.
- To assess the biocompatibility and repair potential of different formulations.
Main Methods:
- Subcutaneous inoculation of isogenic BALB/c mice with various calcium hydroxide pastes (Calen, Calen with additives, Calasept) or control.
- Histopathological evaluation of inflammatory markers at multiple time points.
- Assessment of vascular congestion, edema, infiltrate, necrosis, and repair.
Main Results:
- All tested calcium hydroxide pastes induced inflammatory responses of varying intensity and duration.
- Calen paste showed a shorter-term inflammatory reaction and better biocompatibility.
- Formulations with paramonochlorophenol, especially without camphor, elicited more severe and prolonged tissue reactions; Calasept was more damaging.
Conclusions:
- Calcium hydroxide formulations elicit inflammatory responses, influenced by antiseptic agents.
- The severity and duration of inflammation differ among pastes.
- Despite irritation, all tested formulations supported tissue repair, though at different rates.