Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinolone activity against anaerobes.

P C Appelbaum1

  • 1Department of Pathology, Hershey Medical Center, Pennsylvania 17033, USA.

Drugs
|December 20, 1999
PubMed
Summary

Newer broad-spectrum quinolones show significant activity against anaerobic bacteria, unlike older fluoroquinolones. This review details the in vitro effectiveness of various quinolones against anaerobic pathogens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy·2010
Same author

Postantibiotic effect of ceftaroline against gram-positive organisms.

Antimicrobial agents and chemotherapy·2009
Same author

Bacterial resistance in the new millennium. Its impact on antibiotic selection for respiratory tract infections.

Postgraduate medicine·2009
Same author

Postantibiotic effects of telavancin against 16 gram-positive organisms.

Antimicrobial agents and chemotherapy·2009
Same author

Postantibiotic effect of tigecycline against 14 gram-positive organisms.

Antimicrobial agents and chemotherapy·2008
Same author

Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of Staphylococcus aureus isolates from a patient with persistent bacteraemia and endocarditis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2008

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • First-generation fluoroquinolones exhibit limited efficacy against anaerobic bacteria.
  • Emerging broad-spectrum quinolones demonstrate promising antianaerobic potential.

Purpose of the Study:

  • To review the in vitro activity of available and experimental quinolones against clinically relevant anaerobic bacteria.
  • To compare the antianaerobic spectrum of different quinolone generations.

Main Methods:

  • Systematic review of in vitro studies.
  • Analysis of Minimum Inhibitory Concentrations (MICs) against anaerobic bacterial panels.
  • Categorization of quinolones based on antianaerobic activity.

Main Results:

  • Ciprofloxacin, ofloxacin, levofloxacin, and others show low activity.
  • Sparfloxacin and grepafloxacin possess intermediate antianaerobic activity.
  • Trovafloxacin, gatifloxacin, moxifloxacin, clinafloxacin, and sitafloxacin display significant to potent in vitro activity.

Conclusions:

  • Recent quinolone advancements offer effective therapeutic options against anaerobic infections.
  • Clinafloxacin and sitafloxacin exhibit the highest in vitro antianaerobic potency.
  • Quinolone selection for anaerobic infections should consider spectrum and potency.

Related Experiment Videos