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Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...

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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System

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Published on: September 20, 2019

[T lymphocytes in sarcoidosis].

A Tazi¹, A J Hance

¹Service de Pneumologie, Hôpital Avicenne, Bobigny. abdellatif.tazi@avc.ap-hop-paris.fr

Presse Medicale (Paris, France : 1983)

|November 11, 1999

Summary

T-lymphocytes are crucial in sarcoidosis, an immune disorder. Studies show specific T-cell responses in patients, suggesting antigen triggers, and highlight cytokine modulation for targeted therapies.

Area of Science:

Immunology
Pulmonology
Cellular Biology

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