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Conformational aspects of human formylpeptide receptor antagonists
A Scatturin1, G Vertuani, R Pecoraro
1Department of Pharmaceutical Sciences, Ferrara University, Italy. sca@dns.unife.it
Arzneimittel-Forschung
|November 11, 1999
Abstract:
The conformation of several Phe-D-Leu-Phe-D-Leu-Phe analogues was analyzed using infrared absorption and circular dichroism. Their effect on human neutrophils was verified by receptor binding and chemotaxis assays. The results demonstrate that the compounds examined prefer an ordered conformation (beta-turn) in amphipatic environment, and that they are able to antagonize the neutrophil functions evoked by CHO-Met-Leu-Phe.