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Related Experiment Videos

Novel antitumor agents from higher plants.

K H Lee1

  • 1Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.

Medicinal Research Reviews
|November 11, 1999
PubMed
Summary

Researchers explored plant-derived cytotoxic compounds for cancer treatment. Over 100 compounds showed anti-tumor activity, with one promising drug, GL331, now in clinical trials for drug-resistant cancers.

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Research focuses on cytotoxic natural products from plants for cancer therapy.
  • Extensive preclinical studies have been conducted in Dr. K. H. Lee's Natural Products Laboratory.
  • This work involves lead identification and structural modification of potential anticancer agents.

Purpose of the Study:

  • To review the discovery and development of cytotoxic natural products and their analogs.
  • To highlight compounds with confirmed activity against human tumor cell lines.
  • To discuss promising anticancer drug candidates, including those in clinical trials.

Main Methods:

  • Isolation and structural elucidation of cytotoxic compounds from plant sources, particularly Chinese medicinal herbs.

Related Experiment Videos

  • Bioactivity-directed fractionation guided by in vitro assays.
  • Chemical synthesis and modification of natural product scaffolds.
  • Evaluation of cytotoxic and antitumor activity using NCI's in vitro human tumor cell lines bioassay.

    • Main Results:

    • Over 100 novel cytotoxic antitumor compounds and synthetic analogs have been identified.
    • These compounds demonstrated confirmed activity in NCI's in vitro bioassay.
    • A podophyllotoxin analog, GL331, is in Phase IIa clinical trials and shows promise for drug-resistant cancers.
    • Various classes of cytotoxic compounds were isolated, including polyphenols, lignans, and flavonoids.

    Conclusions:

    • Plant-derived natural products represent a rich source of cytotoxic anticancer agents.
    • Structural modification and preclinical development have yielded promising drug candidates like GL331.
    • Continued research into these compounds holds potential for novel cancer therapeutics, especially for resistant malignancies.