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Simple, rapid thyroid function testing with 99mTc-pertechnetate thyroid uptake ratio and neck/thigh ratio.

P B Schneider

    AJR. American Journal of Roentgenology
    |February 1, 1979
    PubMed
    Summary
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    This study introduces a new method for measuring thyroid function using technetium-99m pertechnetate (99mTcO4-) uptake ratios. This technique accurately identifies hyperthyroid and hypothyroid cases, offering a convenient alternative to traditional uptake measurements.

    Area of Science:

    • Nuclear Medicine
    • Endocrinology
    • Radiopharmacology

    Background:

    • Traditional thyroid uptake measurements using 99mTcO4- face technical challenges, including errors in absolute uptake, extrathyroidal background, and dose standardization.
    • Accurate assessment of thyroid function is crucial for diagnosing and managing thyroid disorders.

    Purpose of the Study:

    • To evaluate techniques for measuring thyroid uptake of 99mTcO4- that are independent of absolute uptake, neck extrathyroidal background, and dose standards.
    • To establish a convenient and accurate method for evaluating thyroid function using 99mTcO4-.

    Main Methods:

    • A series of 108 patients underwent intravenous injection of 2 mCi 99mTcO4-.
    • Radioactivity was recorded over the neck and thigh at specific time points.

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  • Thyroid uptake ratios, including neck/thigh ratios at 15 minutes and 10'/2' thyroid uptake ratios, were calculated.

    • Main Results:

    • A combination of the 15-minute neck/thigh ratio and the 10'/2' thyroid uptake ratio effectively discriminated thyroid function.
    • 92% of hyperthyroid cases were identified by a neck/thigh ratio > 4.7.
    • 95% of hypothyroid cases were identified by a neck/thigh ratio < 3 and a 10'/2' thyroid uptake ratio < 1.
    • Euthyroid classification accuracy was 84%, rising to 91% excluding patients previously treated with 131I.
    • The accuracy of this 99mTc procedure is comparable to standard 24-hour 131I uptake and computer-assisted absolute uptake determinations.

    Conclusions:

    • The evaluated technique provides a convenient and accurate method for thyroid function evaluation.
    • This procedure complements 99mTcO4- thyroid imaging, offering a valuable tool in nuclear medicine.
    • The uptake ratio method overcomes technical difficulties associated with absolute uptake measurements.