Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Aging and the immune system. Experimental aspects].

F Barrat1, B Lesourd, H J Boulouis

  • 1Laboratoire de Microbiologie, Immunologie, Institut National de Recherche Agronomique (INRA), Ecole Nationale Vétérinaire d'Alfort, Maisons, France.

Bulletin De L'Academie Nationale De Medecine
|November 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relevance and Feasibility of a Personalized Dietary Intervention in Older People with Meals-On-Wheels: A Randomized Controlled Pilot Trial.

JAR life·2023
Same author

Bartonella bovis and Bartonella chomelii infection in dairy cattle and their ectoparasites in Algeria.

Comparative immunology, microbiology and infectious diseases·2020
Same author

Conjunctival bacterial and fungal flora and cutaneous fungal flora in healthy domestic rabbits (Oryctolagus cuniculus).

The Journal of small animal practice·2019
Same author

Bovine anaplasmosis and tick-borne pathogens in cattle of the Galapagos Islands.

Transboundary and emerging diseases·2018
Same author

Isolation of Bartonella henselae, Bartonella koehlerae subsp. koehlerae, Bartonella koehlerae subsp. bothieri and a new subspecies of B. koehlerae from free-ranging lions (Panthera leo) from South Africa, cheetahs (Acinonyx jubatus) from Namibia and captive cheetahs from California.

Epidemiology and infection·2016
Same author

Frailty and nutrition: searching for evidence.

The journal of nutrition, health & aging·2015
Same journal

[Advances and perspectives in vascularized composite allotransplantation preservation].

Bulletin de l'Academie nationale de medecine·2025
Same journal

[COVID-19: Neurological manifestations and complications during the acute phase of the disease].

Bulletin de l'Academie nationale de medecine·2024
Same journal

[Role of psychological factors in post-COVID-19 condition].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[From the origin of Sars-CoV-2 to dangerous virology/biology].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[Neurological forms of long COVID in adults: Critical approach].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[Post-COVID-19 syndrome].

Bulletin de l'Academie nationale de medecine·2023
See all related articles

Pregnancy and sex significantly impact immune system aging in mice. Parity influences immune cell distribution and T cell function, potentially explaining women's longer lifespan.

Area of Science:

  • Immunology
  • Aging Research
  • Reproductive Biology

Background:

  • Age-related immune system decline (immunosenescence) is a significant health concern.
  • The influence of reproductive history (parity) and sex on immunosenescence remains understudied.
  • Understanding these factors is crucial for addressing age-related diseases and sex-specific longevity.

Purpose of the Study:

  • To investigate the impact of pregnancies and sex on age-related changes in immune cell populations and T cell function in mice.
  • To compare immune profiles of multiparous females, virgin females, and males across different age groups.

Main Methods:

  • Flow cytometry was used to analyze spleen cell populations (T cells, B cells, macrophages) in mice at 2, 8, 15, and 23 months of age.
  • Development of naive and memory T cells (CD4+ and CD8+) was assessed.

Related Experiment Videos

  • In vitro cytokine secretion (IL-2, IL-4, gamma-interferon, GM-CSF) from activated spleen cells was measured.

    • Main Results:

    • Pregnancy (parity) had both short-term (e.g., preserved IL-2 production) and long-term (e.g., elevated macrophage levels) effects on immune aging.
    • Multiparous females showed delayed memory CD4+ cell appearance and higher IL-4 and GM-CSF production in late adulthood.
    • Sex differences included lower macrophage levels and gamma-interferon secretion in males compared to females in later life.

    Conclusions:

    • Immune cell distribution and T cell function during aging are dependent on parity and sex.
    • These parity- and sex-dependent immune changes may influence age-related disease susceptibility and contribute to observed sex differences in longevity.