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Abstract:
Around 1 in 200 men have abnormally low levels of circulating testosterone that result in hypogonadism. Most of these men should be offered testosterone replacement therapy. Here we outline the rationale for such treatment and the different preparations available. We do not discuss the use of testosterone to induce pubertal development in prepubertal males with hypogonadism.
Insights
Hypogonadism affects about 1 in 200 men, causing low testosterone. Testosterone replacement therapy is recommended for most men with this condition, with various treatment options available.
Area of Science:
- Endocrinology
- Men's Health
Background:
- Hypogonadism is a condition characterized by abnormally low circulating testosterone levels.
- Affects approximately 1 in 200 men.
- Often necessitates medical intervention.
Purpose of the Study:
- To review the rationale for testosterone replacement therapy (TRT).
- To discuss available TRT preparations.
- To provide guidance on TRT for adult hypogonadal males.
Main Methods:
- Literature review of existing studies and clinical guidelines.
- Analysis of the benefits and risks of TRT.
- Comparison of different testosterone formulations.
Main Results:
- TRT is indicated for most men diagnosed with hypogonadism.
- Various formulations exist, including injections, gels, and patches.
- Treatment choice depends on individual patient factors and preferences.
Conclusions:
- Testosterone replacement therapy is a viable treatment for hypogonadism in men.
- Understanding treatment rationale and available preparations is crucial for effective management.
- This review focuses on TRT for adult hypogonadal males, excluding pubertal induction.