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Multipaint FISH: a rapid and reliable way to define cryptic and complex abnormalities.

C A Joyce¹, F M Ross, N R Dennis

¹Wessex Regional Genetics Laboratory, Salisbury Health Care Trust, Salisbury District Hospital, Wilts, UK.

Clinical Genetics

|November 24, 1999

Summary

Multipaint fluorescence in situ hybridisation (FISH) effectively detects complex chromosome abnormalities missed by conventional methods. This rapid technique identifies translocations and rearrangements, aiding in accurate genetic diagnosis.

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Area of Science:

Cytogenetics
Molecular Biology
Genetics

Background:

Conventional cytogenetics has limitations in resolving complex chromosome abnormalities.
Undetected cryptic rearrangements can lead to misdiagnosis and inadequate treatment.

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