Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current and evolving therapies for hepatitis C.

D Moradpour1, H E Blum

  • 1Department of Medicine II, University of Freiburg, Germany. moradpou@ruf.uni-freiburg.de

European Journal of Gastroenterology & Hepatology
|November 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of hepatitis B virus on steatosis in hepatitis C virus co-infected subjects: A multi-centre study and systematic review.

Journal of viral hepatitis·2018
Same author

Trends in hepatitis C-related mortality in Switzerland.

Journal of viral hepatitis·2017
Same author

Access to therapy and therapy outcomes in the Swiss Hepatitis C Cohort Study: a person-centred approach.

Journal of viral hepatitis·2016
Same author

[Hepatitis C: 25 years of progress with still major challenges].

Revue medicale suisse·2015
Same author

The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.

Cell death and differentiation·2015
Same author

Systematic review with meta-analysis: self-expanding metal stents in patients with cirrhosis and severe or refractory oesophageal variceal bleeding.

Alimentary pharmacology & therapeutics·2015
Same journal

Comment on 'Associations between 12 insulin resistance surrogates with metabolic dysfunction-associated steatotic liver disease risk and all-cause mortality: data from the National Health and Nutrition Examination Survey III (1988-1994)'.

European journal of gastroenterology & hepatology·2026
Same journal

Alarm symptoms at diagnosis of coeliac disease and long-term outcomes.

European journal of gastroenterology & hepatology·2026
Same journal

Artificial intelligence-integrated nanotherapeutics for rare Peutz-Jeghers syndrome hamartoma-induced obstructions: latest clearance strategies.

European journal of gastroenterology & hepatology·2026
Same journal

'Presence of alarm symptoms at coeliac disease diagnosis is not associated with poorer long-term treatment outcomes' [Letter].

European journal of gastroenterology & hepatology·2026
Same journal

Atrial fibrillation in patients with alcohol-associated hepatitis leads to increased mortality.

European journal of gastroenterology & hepatology·2026
Same journal

Association between albumin-bilirubin score, model for end-stage liver disease score, platelet-albumin-bilirubin score, and acute-on-chronic liver failure complications: a cross-sectional study in a Chinese population.

European journal of gastroenterology & hepatology·2026
See all related articles

Hepatitis C virus (HCV) infection requires better treatments. New therapies targeting viral replication and immune responses are being explored to improve outcomes for chronic hepatitis C.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis C virus (HCV) infection is a major global cause of liver disease and cancer.
  • Current treatments like interferon-alpha monotherapy have limited efficacy.
  • Combination therapy with interferon-alpha and ribavirin shows improvement but is insufficient.

Purpose of the Study:

  • To review the limitations of current hepatitis C therapies.
  • To explore novel antiviral strategies targeting HCV molecular mechanisms.
  • To discuss emerging gene and immunotherapy approaches for HCV.

Main Methods:

  • Review of recent clinical trials and molecular virology research.
  • Identification of specific viral targets including NS3 protease, helicase, and RNA polymerase.

Related Experiment Videos

  • Exploration of gene therapy and immunotherapy concepts.

    • Main Results:

    • Standard interferon-alpha therapy yields sustained response in only 10-20% of patients.
    • Combination therapy improves response rates but is still suboptimal.
    • New molecular targets and therapeutic strategies are under investigation.

    Conclusions:

    • More effective therapies for hepatitis C are urgently needed.
    • Targeting viral molecular processes and enhancing immune responses represent promising avenues.
    • Novel antiviral strategies hold potential to complement existing treatments for HCV.