Vitamin D and regulation of gene expression
1Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
Abstract:
The function of 1,25-dihydroxyvitamin D3, the biologically active form of vitamin D, extends from bone and mineral homeostasis to the control of cell growth and differentiation in a variety of tissues. Most of these actions are mediated by activation of the nuclear vitamin D receptor, which regulates the transcription of vitamin D target genes. Considerable progress has been made in the understanding of vitamin D receptor function (especially regarding its interaction with coactivators), as well as in the identification of novel vitamin D responsive genes related to cell growth, differentiation and cytokine production.
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