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Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown
1Department of Molecular Pathology, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, U.K. nmilton@rfhsm.ac.uk
The Biochemical Journal
|November 24, 1999
Abstract:
Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.