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Chromatin modification by DNA tracking.

A Travers1

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom. aat@mrc-lmb.cam.ac.uk

Proceedings of the National Academy of Sciences of the United States of America
|November 26, 1999
PubMed
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This summary is machine-generated.

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Chromatin

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Transcriptional competence correlates with DNase I sensitivity.
  • RNA polymerase II activity is linked to histone acetyltransferase activity.
  • Histone acetylation influences chromatin folding and accessibility.

Purpose of the Study:

  • To propose a mechanism for chromatin modification.
  • To explain how chromatin domains maintain an open configuration.
  • To link extragenic transcription to chromatin structure.

Main Methods:

  • Literature review and theoretical modeling.
  • Analysis of existing data on chromatin structure and transcription.
  • Hypothesizing a tracking-mediated chromatin modification process.

Related Experiment Videos

Main Results:

  • Tracking-mediated chromatin modification can create and maintain open chromatin domains.
  • This mechanism applies to both intra- and extragenic regions.
  • Extragenic transcription may play a functional role in chromatin organization.

Conclusions:

  • A processive mechanism involving RNA polymerase II and histone acetylation can alter chromatin states.
  • Extragenic transcription may contribute to maintaining an open chromatin configuration.
  • This model provides a functional role for observed extragenic transcription patterns.