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Vesicoureteric reflux in children: an update
V Fanos1, R Agostiniani, L Cataldi
1Clinica Pediatrica, Università di Verona, Italia.
La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|November 26, 1999
Summary
Recent studies reveal advancements in understanding the genetic and pathogenetic mechanisms of childhood vesicoureteric reflux (VUR). Research highlights distinct clinical presentations and improved diagnostic tools for this condition.
Area of Science:
- Pediatric Urology
- Genetics
- Pathophysiology
Background:
- Vesicoureteric reflux (VUR) in children is a significant concern.
- Understanding its genetic basis and development is crucial for effective management.
- Recent literature provides updated insights into VUR.
Purpose of the Study:
- To review recent significant studies on pediatric VUR.
- To highlight advancements in understanding VUR's genetics and pathogenesis.
- To discuss high-risk populations, clinical presentations, and diagnostic methods.
Main Methods:
- Comprehensive review of studies published in the last two years.
- Analysis of research on genetic implications and pathogenetic mechanisms.
- Evaluation of new instrumental and laboratory investigations.
Main Results:
- Significant progress in understanding the genetic and pathogenetic factors of VUR.
- Identification of distinct clinical presentations, suggesting VUR is not a single entity.
- Availability of novel diagnostic and laboratory tools for VUR assessment.
Conclusions:
- Childhood VUR is complex, with varying genetic and pathogenetic underpinnings.
- Two primary clinical pictures of VUR can be distinguished.
- New diagnostic approaches and a better understanding of natural history and surgical treatments are available.