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Posterior uveitis in Hodgkin's disease
H Towler1, M de la Fuente, S Lightman
1Department of Clinical Ophthalmology, Moorfields Eye Hospital, Institute of Ophthalmology, London, UK.
Insights
Hodgkin's disease (HD) can manifest in the eye, mimicking posterior uveitis. Ocular signs like vitritis and chorioretinal lesions were observed, sometimes preceding HD diagnosis.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Posterior uveitis can present with varied etiologies.
- Hodgkin's disease (HD) is a lymphoma that can rarely involve ocular structures.
Observation:
- A retrospective review of four patients with biopsy-proven Hodgkin's disease (HD) and posterior uveitis was conducted.
- Ocular findings included vitritis and discrete, white, chorioretinal lesions.
- Two patients presented with uveitis before HD diagnosis; two had HD in remission.
Findings:
- Hodgkin's disease (HD) can present as posterior uveitis.
- Vitritis and chorioretinal lesions were the most common ocular signs.
- No distinct ocular features differentiated patients with known HD from those without.
Implications:
- Ocular inflammation, particularly posterior uveitis, should raise suspicion for underlying Hodgkin's disease (HD).
- Early detection of HD may be facilitated by recognizing these ocular manifestations.
- Further research is needed to identify specific diagnostic markers for HD-associated uveitis.
Purpose:
To describe the features of posterior uveitis in patients who either developed or were known to have, biopsy-proven Hodgkin's disease (HD).
Methods:
Four patients were identified who were attending the uveitis clinic. Their charts were reviewed retrospectively and information on their HD was obtained from other hospitals where necessary. Their case histories are presented.
Results:
Two patients presented with uveitis prior to the diagnosis of HD and in the other two, the HD was thought to be in remission. The commonest ocular signs were of vitritis and discrete, white, chorioretinal lesions. No difference in the ocular findings were apparent between those who had a known diagnosis of HD and the those that did not.
Conclusions:
HD can occur in the eye and can mimic posterior uveitis. In two of the patients, the uveitis preceded the diagnosis of HD and at the time of presentation all investigations were normal. No specific diagnostic features were apparent, though three of the patients had vitritis and chorioretinal lesions.