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Related Experiment Video

Updated: Jul 20, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men.

G Nickenig¹, A T Bäumer, Y Temur

¹Klinik III für Innere Medizin, Universität Köln, Germany. georg.nickenig@uni-koeln.de

|November 26, 1999

Summary

High cholesterol in men increases angiotensin II type 1 receptor expression and blood pressure response. Statins effectively lower this receptor expression and improve blood pressure, offering new therapeutic avenues.

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Last Updated: Jul 20, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

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Published on: September 28, 2015

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

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Published on: June 7, 2016

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Area of Science:

Cardiovascular Science
Endocrinology
Pharmacology

Background:

Hypercholesterolemia is linked to increased vascular angiotensin II type 1 (AT1) receptor expression.
Previous research showed this effect in cell cultures and animal models.

Purpose of the Study:

To investigate AT1 receptor overexpression in hypercholesterolemic men.
To evaluate the therapeutic effects of HMG CoA reductase inhibitors (statins) on AT1 receptor expression and function.

Main Methods:

Assessed blood pressure response to angiotensin II infusion in normocholesterolemic and hypercholesterolemic men.
Measured AT1 receptor expression on isolated platelets.
Evaluated patients before and after statin therapy.

Main Results:

Hypercholesterolemia significantly increased angiotensin II-induced blood pressure elevation.
AT1 receptor expression was significantly higher in hypercholesterolemic individuals.
Statin treatment reversed the elevated blood pressure response and downregulated AT1 receptor density.

Conclusions:

Hypercholesterolemia induces AT1 receptor overexpression and enhances angiotensin II effects in men.
Findings offer insights into hypertension and atherosclerosis pathogenesis.
Suggests potential for new therapeutic strategies targeting AT1 receptors.