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[The antioxidant effects of amtizol and trimetazidine]
A V Smirnov1, B I Krivoruchko, I V Zarubina
1Department of Pharmacology, Russian Federation Military Medical Academy, St. Petersburg, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|November 26, 1999
Abstract:
Experiments were conducted on rats to study the antioxidant effects of amtisol and trimethasidin (25 mg/kg) in incomplete cerebral ischemia complicated by hypoxia. Amtisol as well as trimethasidin inhibited activation of lipid peroxidation (LPO) and prevented decrease in activity of the antioxidant system. In in vitro experiments amtisol and trimethasidin blocked epinephrine auto-oxidation. Amtisol inhibited ascorbate-dependent LPO in the liposomes and metabolizing model system, inhibited fermentative NADP-dependent POL in brain tissue homogenates.