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Effect of formulation variables on cis-platin loaded chitosan microsphere properties
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Turkey.
Journal of Microencapsulation
|November 27, 1999
Summary
This study developed cisplatin-loaded chitosan microspheres for drug delivery. Key factors like chitosan type and oil influenced drug entrapment and release, achieving high incorporation efficiency.
Area of Science:
- Biomaterials Science
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Chitosan microspheres offer a promising platform for controlled drug delivery.
- Cisplatin is a widely used chemotherapeutic agent with limitations in administration and side effects.
Purpose of the Study:
- To prepare and characterize chitosan microspheres loaded with cisplatin using a water-in-oil emulsion system.
- To investigate the impact of various formulation parameters on cisplatin entrapment and release kinetics.
Main Methods:
- Preparation of chitosan microspheres via water-in-oil emulsion.
- Systematic variation of chitosan concentration, cisplatin concentration, glutaraldehyde concentration, oil type, and stirring rate.
- Evaluation of cisplatin incorporation efficiency and in vitro release profiles.
Main Results:
- Chitosan and glutaraldehyde concentrations, along with oil and chitosan types, significantly influenced cisplatin entrapment.
- Incorporation efficiency ranged broadly from 28% to 99%.
- Chitosan type, concentration, and oil type critically affected cisplatin release, which exhibited an initial burst effect.
Conclusions:
- Formulation parameters significantly control the properties of cisplatin-loaded chitosan microspheres.
- The developed microspheres demonstrate potential for cisplatin delivery, with tunable release characteristics.
- Further optimization is warranted to refine release profiles and minimize burst release.