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Updated: Aug 9, 2026

06:40
Mouse Fetal Liver Culture System to Dissect Target Gene Functions at the Early and Late Stages of Terminal Erythropoiesis
Published on: September 9, 2014
Loss with age in the capacity for erythrogenin production by extrarenal tissues in rats
Abstract:
Erythrogenin levels in liver and spleen were compared in young and adult anephric rats exposed to 6h of hypoxia. Hepatic and splenic erythrogenin levels in young nephrectomized rats were significantly higher than those in anephric adults. This lowered ability of the adult rat to elaborate extrarenal erythrogenin may be related to a decrease in selective enzyme production which accompanies the aging process.

