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THE RETICULO-ENDOTHELIAL SYSTEM AND HORMONE REFRACTORINESS.

A S Gordon¹, W Kleinberg, H A Charipper

¹Department of Biology, Washington Square College, New York University, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

The spleen and reticulo-endothelial system influence hormone responses. Removing the spleen or impairing the reticulo-endothelial system enhances ovarian and thyroid activity, suggesting their role in producing antihormone substances.

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Area of Science:

Endocrinology
Immunology
Physiology

Background:

The spleen and reticulo-endothelial system (RES) play crucial roles in immune function and homeostasis.
Hormonal regulation is complex and can be influenced by various physiological factors.
Antihormone substances are known to modulate the effects of administered hormones.

Purpose of the Study:

To investigate the influence of the spleen and RES on hormonal responses in rats and guinea pigs.
To determine if the RES participates in the production of antihormone substances.
To explore the relationship between RES integrity and reproductive and thyroid hormone sensitivity.

Main Methods:

Spleen removal (splenectomy) and RES blockade using trypan blue in rats and guinea pigs.
Administration of pregnant mare's serum and pregnancy urine extract to assess ovarian, testicular, and seminal vesicle responses.
Injection of thyrotropic extract to evaluate thyroid function.
Plasma analysis for antihormone substance levels.

Main Results:

Splenectomized rats showed increased ovarian weight response to pregnant mare's serum compared to normal rats.
RES blockade with trypan blue prevented ovarian weight regression in splenectomized rats.
Bartonella muris infection (injuring RES) also enhanced ovarian response to pregnant mare's serum.
Similar effects were observed on male reproductive organs and thyroids in splenectomized/RES-impaired animals.
Plasmatic antihormone substance levels were lower in splenectomized and RES-blocked animals.

Conclusions:

The reticulo-endothelial system is implicated in the production of antihormone substances.
Spleen and RES integrity significantly modulate the body's response to exogenous hormones.
Disruption of the spleen or RES can lead to enhanced sensitivity to reproductive and thyroid hormones.