Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonequilibrium migration in human history.

J Wakeley1

  • 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. jwakeley@oeb.harvard.edu

Genetics
|December 3, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extending coalescent theory to autotetraploids.

Genetics·2012
Same author

The excess of transitions among nucleotide substitutions: new methods of estimating transition bias underscore its significance.

Trends in ecology & evolution·2011
Same author

Expected coalescence times and segregating sites in a model of glacial cycles.

Genetics and molecular research : GMR·2006
Same author

Effects of intra-gene fitness interactions on the benefit of sexual recombination.

Biochemical Society transactions·2006
Same author

Recent trends in population genetics: more data! More math! Simple models?

The Journal of heredity·2004
Same author

A robust measure of HIV-1 population turnover within chronically infected individuals.

Molecular biology and evolution·2004
Same journal

Coexistence of piRNA and KZFP defense systems: Evolutionary dynamics of layered defense against transposable elements.

Genetics·2026
Same journal

Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase.

Genetics·2026
Same journal

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

Genetics·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
See all related articles

A new migration model suggests human population size decreased due to increased migration rates. This genetic analysis reveals shifts in effective population size, impacting human evolutionary studies.

Area of Science:

  • Population Genetics
  • Evolutionary Biology
  • Human Demography

Background:

  • Understanding human population history relies on genetic models.
  • Migration patterns significantly influence genetic diversity and effective population size.

Purpose of the Study:

  • To develop and apply a nonequilibrium migration model to human genetic data.
  • To investigate demographic changes, specifically effective population size shifts, in human evolution.

Main Methods:

  • Proposed a nonequilibrium migration model with symmetric migration among large numbers of demes.
  • Derived expressions for expected numbers of segregating sites at various frequencies in multideme samples.
  • Utilized maximum-likelihood analysis on independent polymorphic restriction sites in human DNA.

Related Experiment Videos

Main Results:

  • The model identified a decrease in ancestral effective population size in humans.
  • Analysis indicated a significant change in demographic parameters, consistent with altered migration rates.
  • Observed a shift from ancient low migration rates to present high migration rates among human subpopulations.

Conclusions:

  • The study provides evidence for a demographic transition in human history.
  • Increased migration rates correlate with a decrease in effective population size.
  • The developed model offers a framework for analyzing demographic changes in other species.