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Mitochondrial DNA polymorphism in the Vietnamese population.

R Ivanova1, A Astrinidis, V Lepage

  • 1INSERM U396, Hopital St. Louis, Paris, France.

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
|December 3, 1999
PubMed
Summary

Mitochondrial DNA analysis of 50 Vietnamese individuals revealed genetic diversity and new markers. Findings suggest a dual ethnic origin for the Vietnamese population, linking them to Chinese and Thai-Indonesian ancestries.

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Area of Science:

  • Genetics
  • Population Genetics
  • Molecular Anthropology

Background:

  • Mitochondrial DNA (mtDNA) variation is crucial for understanding population history and migration patterns.
  • Previous studies suggest complex origins for East Asian populations, but specific details for the Vietnamese population remain under investigation.

Purpose of the Study:

  • To investigate the mitochondrial DNA variation in the Vietnamese population from Hanoi.
  • To identify novel genetic markers and compare Vietnamese mtDNA profiles with other East Asian populations.
  • To explore the genetic basis supporting a dual ethnic origin hypothesis for the Vietnamese.

Main Methods:

  • Screening of mitochondrial DNA variation in 50 unrelated Vietnamese individuals.
  • Utilizing long and standard PCR combined with restriction endonuclease digests (HpaI, BamHI, HaeII, MspI, AvaII, HincII).

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  • Analysis of the 9-bp deletion in the COII/tRNALys region of the mitochondrial genome.

    • Main Results:

    • Twenty enzyme morphs were detected, including three novel morphs (HaeII-13Viet, MspI-19Viet, MspI-20Viet).
    • Ten known and four new mitotypes were identified. The 9-bp deletion was present in 10 samples.
    • Vietnamese population shows close genetic ties to other East Asians but is distinct due to a higher frequency of HincII-5 and seven new markers.

    Conclusions:

    • The study identified significant mitochondrial DNA variation within the Vietnamese population.
    • Distinct genetic markers differentiate the Vietnamese from other East Asian populations.
    • Results provide genetic support for a dual ethnic origin of the Vietnamese, with contributions from Chinese and Thai-Indonesian groups.