"Itching" for new strategies in protein engineering

Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes.

Protein engineering, design & selection : PEDS·2015

Uncovering rare NADH-preferring ketol-acid reductoisomerases.

Metabolic engineering·2014

How proteins adapt: lessons from directed evolution.

Cold Spring Harbor symposia on quantitative biology·2010

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo.

Proceedings of the National Academy of Sciences of the United States of America·2007

The transition state of the ras binding domain of Raf is structurally polarized based on Phi-values but is energetically diffuse.

Journal of molecular biology·2006

Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability.

Journal of molecular biology·2006

High numerical aperture confocal volumetric mesoscope reveals mesoscale subcellular dynamics in vivo.

Nature biotechnology·2026

High-fidelity fast fluorescence lifetime imaging by event-based denoising.

Nature biotechnology·2026

Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse.

Nature biotechnology·2026

High-resolution reconstruction of cell-type-specific transcriptional regulatory processes from bulk sequencing samples.

Nature biotechnology·2026

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition.

Nature biotechnology·2026

Engineered ADARs enable precision A-to-G base editing of DNA.

Nature biotechnology·2026

Programmable DNA nanowires mediated dispersion-to-localization catalytic hairpin assembly for high-contrast miRNA detection and imaging.

Biosensors & bioelectronics·2026

Enhanced production of bacterial nanocellulose by <i>Bacillus subtilis</i> using combined mutagenesis and response surface optimization approaches.

Preparative biochemistry & biotechnology·2026

On-demand growth of semiconductor heterostructures guided by physics-informed machine learning.

Science advances·2026

Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides.

Angewandte Chemie (International ed. in English)·2026

Self-driving lab for the data-driven design of single-chain polymer nanoparticles.

Cell press blue·2026

Highly Controlled Nanostructured CuO Photocathodes.

ACS applied nano materials·2026

Related Experiment Videos

"Itching" for new strategies in protein engineering

Related Concept Videos

Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes.

Uncovering rare NADH-preferring ketol-acid reductoisomerases.

How proteins adapt: lessons from directed evolution.

Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo.

The transition state of the ras binding domain of Raf is structurally polarized based on Phi-values but is energetically diffuse.

Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability.

High numerical aperture confocal volumetric mesoscope reveals mesoscale subcellular dynamics in vivo.

High-fidelity fast fluorescence lifetime imaging by event-based denoising.

Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse.

High-resolution reconstruction of cell-type-specific transcriptional regulatory processes from bulk sequencing samples.

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition.

Engineered ADARs enable precision A-to-G base editing of DNA.

Programmable DNA nanowires mediated dispersion-to-localization catalytic hairpin assembly for high-contrast miRNA detection and imaging.

Enhanced production of bacterial nanocellulose by <i>Bacillus subtilis</i> using combined mutagenesis and response surface optimization approaches.

On-demand growth of semiconductor heterostructures guided by physics-informed machine learning.

Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides.

Self-driving lab for the data-driven design of single-chain polymer nanoparticles.

Highly Controlled Nanostructured CuO Photocathodes.

Related Experiment Videos

"Itching" for new strategies in protein engineering

Related Concept Videos

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