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[Synthesis of 18F-FDG with FDG MicroLab system: basic studies for clinical application].
1Department of Tracer Kinetics, Hokkaido University School of Medicine.
Kaku Igaku. the Japanese Journal of Nuclear Medicine
|December 10, 1999
Summary
The automated FDG MicroLab system efficiently produces high-purity 18F-FDG for clinical use. This automated synthesis ensures reproducible quality, making it suitable for routine production of this vital radiotracer.
Area of Science:
- Nuclear Medicine
- Radiochemistry
- Medical Imaging
Background:
- 18F-FDG (Fluorodeoxyglucose) is a crucial positron emission tomography (PET) radiotracer.
- Automated synthesis systems are essential for reliable and efficient radiotracer production.
- Assessing the feasibility of automated systems for routine clinical production is vital.
Purpose of the Study:
- To evaluate the quality and reproducibility of 18F-FDG synthesized using the automated "FDG MicroLab" apparatus.
- To determine the suitability of the FDG MicroLab for routine clinical production of 18F-FDG.
Main Methods:
- 18F-FDG was synthesized using the automated "FDG MicroLab" system via solid-phase 18F-fluorination.
- Five consecutive synthesis runs were performed with specific irradiation parameters (15 microA for 60 min).
- Quality control parameters were assessed according to established standards (RADIOISOTOPES, 44, 1995).
Main Results:
- The FDG MicroLab system produced 18F-FDG with an end-of-synthesis yield of 9.34 +/- 1.06 GBq within 50 minutes post-EOB.
- The average radiochemical yield was 47 +/- 3% (decay corrected), and radiochemical purity was 98.0 +/- 0.5%.
- All tested quality control parameters met the required standards.
Conclusions:
- The automated "FDG MicroLab" apparatus demonstrates stable and reproducible production of high-yield, high-purity 18F-FDG.
- The system is feasible and suitable for routine clinical production of 18F-FDG.
- This automated synthesis contributes to the reliable supply of essential PET imaging agents.