Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Infant BCG vaccination study in Lithuania.

E Suciliene1, T Rønne, A M Plesner

  • 1Republican Hospital of Tuberculosis and Lung Diseases, Vilnius, Lithuania.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|December 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia.

BJOG : an international journal of obstetrics and gynaecology·2014
Same author

International Standard for Antistreptolysin-O.

Bulletin of the World Health Organization·2010
Same author

Setting truncation limits for marker values in medical screening.

Journal of medical screening·2007
Same author

Measles outbreak in the Øresund region of Denmark and Sweden.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2006
Same author

Control of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in a day-care institution.

The Journal of hospital infection·2006
Same author

First trimester Down syndrome screening: distribution of markers and comparison of assays for quantification of pregnancy-associated plasma protein-A.

Scandinavian journal of clinical and laboratory investigation·2006

The Danish BCG vaccine induced stronger tuberculin reactions and larger scars when administered at 3 months versus at birth. Vaccination timing significantly impacts BCG vaccine efficacy in infants.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Bacille Calmette-Guérin (BCG) vaccination is crucial for preventing tuberculosis (TB) in infants.
  • Evaluating different BCG vaccine strains and vaccination schedules is essential for optimizing TB prevention strategies.
  • The Danish strain 1331 and the WHO International Reference Preparation (IRP) are commonly used BCG vaccines.

Purpose of the Study:

  • To compare the immunogenicity of the Danish BCG vaccine (strain 1331) against the WHO IRP vaccine in neonates.
  • To assess the impact of BCG vaccine dosage and age at vaccination on tuberculin reactivity and scar formation.
  • To determine the optimal vaccination strategy for BCG in newborns.

Main Methods:

  • A randomized four-armed study was conducted in Vilnius, Lithuania, involving neonates.

Related Experiment Videos

  • Vaccination groups included: normal dose Danish vaccine at birth, half dose Danish vaccine at birth, normal dose IRP vaccine at birth, and normal dose Danish vaccine at 3 months.
  • Tuberculin reactivity and scar formation were measured to evaluate vaccine efficacy.

    • Main Results:

    • Vaccination with the Danish BCG vaccine at 3 months of age resulted in significantly larger tuberculin reactions and scars compared to neonatal vaccination.
    • The WHO IRP vaccine showed borderline significantly larger reactions than the Danish vaccine.
    • Reducing the Danish vaccine dose did not significantly alter reaction size, though smaller reactions were observed.

    Conclusions:

    • Administering the Danish BCG vaccine at 3 months of age enhances its immunogenicity, leading to stronger tuberculin responses and more prominent scars.
    • The WHO IRP vaccine may elicit a stronger reaction than the Danish strain 1331.
    • Vaccination timing is a critical factor influencing BCG vaccine effectiveness in infants, suggesting a potential benefit of delayed vaccination.