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Optimal injection protocol for CT evaluation during hepatic arterial infusion chemotherapy
M Morimoto1, M Satake, R Sekiguchi
1Department of Radiology, National Cancer Center Hospital East, Kashiwa City, Chiba, Japan.
Investigative Radiology
|December 10, 1999
Summary
Computed tomography (CT) is more effective for monitoring hepatic arterial infusion chemotherapy than radioisotope perfusion scintigraphy (RI) or digital subtraction angiography (AG). CT offers superior visualization of both intrahepatic and extrahepatic drug distribution.
Area of Science:
- Medical Imaging
- Oncology
- Interventional Radiology
Background:
- Hepatic arterial infusion chemotherapy (HAIC) is a treatment for liver metastases.
- Effective monitoring of drug distribution is crucial for HAIC efficacy.
- Conventional imaging modalities have limitations in visualizing drug delivery.
Purpose of the Study:
- To evaluate the usefulness of computed tomography (CT) for monitoring HAIC.
- To compare CT with radioisotope perfusion scintigraphy (RI) and digital subtraction angiography (AG).
Main Methods:
- Eight patients with colon cancer hepatic metastases receiving HAIC via reservoir ports were studied.
- Contrast-enhanced CT, RI, and AG were performed to assess drug distribution.
- CT utilized three different contrast infusion rates.
Main Results:
- CT at 0.1 mL/sec infusion rate demonstrated superior visualization of intrahepatic drug distribution compared to RI and AG.
- CT excelled in delineating small intrahepatic areas and provided 3D visualization.
- CT also outperformed RI and AG in evaluating abnormal extrahepatic drug distribution.
Conclusions:
- CT is a more useful imaging modality for follow-up during HAIC than conventional RI and AG.
- CT provides enhanced visualization of both intrahepatic and extrahepatic drug distribution.
- 3D delineation capability of CT aids in treatment assessment.