Chlorofluorocarbon to hydrofluoroalkane formulations: an industry perspective
1Respiratory Therapeutic Development, Group Medical, Regulatory & Product Strategy, Glaxo Wellcome Research & Development, Uxbridge, United Kingdom.
The Journal of Allergy and Clinical Immunology
|December 10, 1999
Summary
Asthma inhalers are transitioning from chlorofluorocarbons to ozone-friendly hydrofluoroalkanes. This global reformulation ensures patient acceptance and environmental safety for metered dose inhalers (MDIs).
Area of Science:
- Pharmaceutical aerosol technology
- Environmental science
- Respiratory medicine
Background:
- Metered dose inhalers (MDIs) are a primary treatment for asthma.
- Chlorofluorocarbons (CFCs) used in MDIs pose environmental risks.
- The pharmaceutical industry sought alternatives to CFCs starting in the late 1980s.
Purpose of the Study:
- To address the environmental impact of chlorofluorocarbons in asthma inhalers.
- To detail the transition to environmentally safer propellant alternatives.
- To report on the global research and development efforts and market introduction of new inhaler technologies.
Main Methods:
- Industry-wide collaboration through the International Pharmaceutical Aerosol Consortium (IPAC).
- Extensive research and development to identify and implement alternative propellants.
- Clinical testing and market launch of new formulations.
Main Results:
- Hydrofluoroalkanes (HFAs) identified as suitable, chlorine-free alternatives to CFCs.
- Significant global investment exceeding $1.0 billion in research and development.
- Successful launch of non-CFC MDIs in Europe, with high patient acceptance.
Conclusions:
- The transition to hydrofluoroalkane metered dose inhalers is environmentally beneficial and clinically successful.
- Continued stakeholder dialogue is crucial for managing the global transition of asthma inhaler technology.
- Patient acceptance of new, environmentally friendly asthma inhaler formulations is high.
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