Related Experiment Video
Updated: Aug 8, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
Pharmacologic considerations in the treatment of neonatal septicemia and its complications
M E Wichtel1, E Buys, J DeLuca
1Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada. mwichtel@upei.ca
Abstract:
This article focuses on the pharmacologic properties of drugs commonly used in the treatment of neonatal septicemia and its complications. Rational therapy demands an awareness of not only the pharmacology of individual drugs but also the interactions and anticipated fate of such drugs in the rapidly changing physiologic environment of the neonate. Further research in the area of equine neonatal pharmacology should greatly assist our understanding of the impact of the disease state on the unique physiology of the newborn and should allow us to better predict the ultimate fate of drugs commonly used for such purposes. Careful dosing and close monitoring of pharmacologic effects are critical for a successful outcome. In the future, newer therapeutic strategies that are safe and efficacious may provide a means to circumvent many of the problems currently encountered with treating the septicemic newborn foal.
Related Concept Videos
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Drug Dosing: Infants and Children
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Distribution
Acute Pyelonephritis II: Diagnostic Studies and Management
Bacterial Meningitis I: Introduction

