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Propofol decreases diaphragmatic contractility in dogs
Y Fujii1, T Hoshi, S Takahashi
1Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.
Anesthesia and Analgesia
|December 10, 1999
Summary
Propofol, an intravenous anesthetic, was found to decrease diaphragmatic contractility in dogs. This effect was dose-related, with higher doses causing a more significant reduction in diaphragm function.
Area of Science:
- Anesthesiology
- Respiratory Physiology
- Veterinary Medicine
Background:
- Volatile anesthetics are known to impair diaphragmatic muscle function.
- Limited data exist on the impact of propofol on diaphragmatic contractility.
Purpose of the Study:
- To investigate the effect of propofol on diaphragmatic contractility in a canine model.
- To determine if the effect is dose-dependent.
Main Methods:
- Canine subjects were divided into three groups: control, subhypnotic propofol, and anesthetic propofol.
- Diaphragmatic contractility was assessed using transdiaphragmatic pressure (Pdi) measurements.
- Low-frequency (20-Hz) and high-frequency (100-Hz) nerve stimulation were used to evaluate Pdi.
Main Results:
- Propofol administration led to a significant decrease in Pdi at 20-Hz stimulation in both subhypnotic and anesthetic dose groups.
- No significant change in Pdi was observed at 100-Hz stimulation.
- The reduction in Pdi was more pronounced at the anesthetic dose of propofol compared to the subhypnotic dose.
Conclusions:
- Propofol exhibits a dose-related inhibitory effect on canine diaphragmatic contractility.
- Both subhypnotic and anesthetic doses of propofol can decrease diaphragm function.