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Measles virus induces functional TRAIL production by human dendritic cells
P O Vidalain1, O Azocar, B Lamouille
1Laboratoire d'Immunobiologie Fondamentale et Clinique, INSERM U503, ENS de Lyon, 69364 Lyon Cedex 07, France. povidala@ens-lyon.fr
Journal of Virology
|December 10, 1999
Abstract:
Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway.