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Papillomaviruses in human cancers.

H zur Hausen1

  • 1Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Proceedings of the Association of American Physicians
|December 11, 1999
PubMed
Summary

Human papillomaviruses (HPV) are complex pathogens, with specific types like HPV 16 and 18 causing most cervical cancers. Research is exploring HPV vaccines to reduce global cancer incidence.

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Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression.

Oncogene·2001

Area of Science:

  • Virology
  • Oncology
  • Molecular Biology

Background:

  • Human papillomaviruses (HPV) represent a complex group of human pathogenic viruses, with 85 characterized genotypes and numerous putative novel types.
  • Specific HPV types, particularly HPV 16 and 18, are implicated in the majority of cervical cancers and precursor lesions.
  • The viral oncogenes E6 and E7 play critical roles in the development and progression of HPV-associated cancers.

Purpose of the Study:

  • To summarize the complexity of human papillomaviruses and their role in oncogenesis.
  • To highlight the significance of HPV types 16 and 18 in cervical cancer etiology.
  • To discuss the potential impact of HPV vaccines on global cancer rates.

Main Methods:

  • Review of characterized HPV genotypes and their association with human cancers.
  • Analysis of the function of viral oncogenes E6 and E7 in cell cycle regulation.
  • Overview of ongoing clinical trials for HPV vaccines.

Main Results:

  • HPV types 16 and 18 are major causative agents of cervical cancers.
  • HPV oncogenes E6 and E7 interfere with cellular regulatory proteins.
  • Papillomaviruses are suspected in oropharyngeal, skin, and esophageal cancers.

Conclusions:

  • HPV vaccines targeting types 16 and 18 show promise for preventing and treating HPV-related cancers.
  • Global implementation of effective HPV vaccines could significantly decrease worldwide cancer incidence.
  • Further research into partially characterized HPV isolates is warranted.

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