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Related Experiment Videos

Smoking and panic attacks: an epidemiologic investigation.

N Breslau1, D F Klein

  • 1Department of Psychiatry, Henry Ford Health System, Detroit, Mich 48202-3450, USA. nbresla1@hfhs.org

Archives of General Psychiatry
|December 11, 1999
PubMed
Summary

Smoking increases the risk of panic attacks, especially in active smokers. This study suggests a potential causal link between smoking and panic disorder, possibly mediated by lung disease.

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Area of Science:

  • Epidemiology
  • Psychiatry
  • Public Health

Background:

  • Epidemiologic studies indicate a lifelong association between smoking and panic disorder.
  • This research investigates potential causal pathways underlying this observed link.

Purpose of the Study:

  • To examine the directionality of the relationship between smoking and panic disorder.
  • To explore potential mediating factors, such as lung disease, in the smoking-panic disorder association.

Main Methods:

  • Utilized data from two large epidemiologic studies: the Epidemiologic Study of Young Adults and the National Comorbidity Survey Tobacco Supplement.
  • Employed Cox proportional hazards models with time-dependent covariates to assess risks for panic attack onset related to smoking history and vice versa.
  • Controlled for history of major depression and explored the role of lung disease.

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Main Results:

  • Daily smoking significantly increased the risk of experiencing a first panic attack or panic disorder.
  • The risk was notably higher for active smokers compared to past smokers.
  • No significant increase in daily smoking onset was observed in individuals with pre-existing panic attacks or disorder.
  • Lung disease emerged as a potential mechanism linking smoking to panic attacks.

Conclusions:

  • Findings support a potential causal hypothesis for the smoking-panic attack relationship, with evidence suggesting influence from prior smoking to panic attack onset.
  • The elevated risk in active smokers warrants further investigation into the specific mechanisms involved.
  • The results highlight the importance of considering smoking cessation interventions for individuals with panic disorder.