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Related Experiment Videos

Ceftriaxone-associated nephrolithiasis and biliary pseudolithiasis.

R A de Moor1, A C Egberts, C H Schröder

  • 1Department of Pediatrics, Tweesteden Hospital, PO Box 90107, 5000 LA Tilburg, The Netherlands.

European Journal of Pediatrics
|December 11, 1999
PubMed
Summary

Ceftriaxone can cause biliary pseudolithiasis and kidney stones. This case highlights these risks occurring rapidly in a child, suggesting prompt ultrasound and antibiotic review for abdominal pain.

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Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Pharmacology

Background:

  • Ceftriaxone is a common antibiotic.
  • Biliary pseudolithiasis and nephrolithiasis are known adverse effects of ceftriaxone.
  • These effects typically manifest after 7-10 days of treatment.

Observation:

  • A 7-year-old boy developed biliary pseudolithiasis and nephrolithiasis.
  • These adverse effects occurred just 4 days after starting ceftriaxone treatment.
  • The patient experienced colicky abdominal pain.

Findings:

  • This case demonstrates a significantly accelerated onset of ceftriaxone-associated biliary and renal complications.
  • The rapid development suggests a potential dose-dependent or individual susceptibility factor.

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  • Ultrasound confirmed the presence of biliary sludge and kidney stones.

    • Implications:

    • Clinicians should consider ceftriaxone-induced biliary pseudolithiasis and nephrolithiasis even with short-term, high-dose therapy.
    • Prompt diagnostic ultrasound is recommended for pediatric patients on ceftriaxone presenting with colicky abdominal pain.
    • Evaluating alternative antibiotic options may be necessary to mitigate these risks.