Integrating functional genomic information into the Saccharomyces genome database.

Area of Science:

• Genomics
• Bioinformatics
• Molecular Biology

Background:

• The Saccharomyces Genome Database (SGD) is a primary resource for yeast gene information.
• Integrating diverse functional genomics data into a centralized database is crucial for research.
• Existing SGD locus pages require updates to incorporate emerging data types.

Purpose of the Study:

• To describe the reorganization and new features of the SGD locus page.
• To enhance the integration of yeast gene information with functional analysis data.
• To improve user access to comprehensive and systematically analyzed gene data.

Main Methods:

• Reorganization of the SGD locus page structure.
• Integration of functional analysis data from literature and web resources.
• Development and implementation of a controlled vocabulary for gene product attributes (cellular process, function, localization) in collaboration with other model organism databases.

Main Results:

• The reorganized locus page provides a more integrated view of yeast gene information.
• New features include searches for systematic analyses and Gene Summary Paragraphs.
• Standardized descriptions of gene product cellular process, function, and localization are now available.

Conclusions:

• The enhanced SGD locus page facilitates a more comprehensive understanding of yeast genes.
• These developments improve the discoverability and utility of yeast genomic and functional data.
• SGD continues to evolve as a key resource for the Saccharomyces cerevisiae research community.