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Published on: July 27, 2010
SELEX_DB: an activated database on selected randomized DNA/RNA sequences addressed to genomic sequence annotation
J V Ponomarenko1, G V Orlova, M P Ponomarenko
1Laboratory of Theoretical Genetics, Institute of Cytology, 10 Lavrentyev Avenue, Novosibirsk 630090, Russia. jpon@bionet.nsc.ru
Nucleic Acids Research
|December 11, 1999
Summary
SELEX_DB is a new database for curated DNA/RNA sequences from SELEX technologies. It aids in identifying functional sites in arbitrary nucleotide sequences.
Area of Science:
- Molecular Biology
- Bioinformatics
- Computational Biology
Background:
- Systematic Evolution of Ligands by Exponential Enrichment (SELEX) technologies generate functional DNA/RNA sequences.
- Experimental data on these functional sequences are crucial for understanding molecular interactions.
- A centralized repository for SELEX-derived data is needed.
Purpose of the Study:
- To introduce SELEX_DB, a novel curated database for SELEX-derived sequences.
- To provide tools for DNA/RNA functional site recognition.
- To facilitate the accumulation and accessibility of experimental data.
Main Methods:
- Curated collection of experimental data from SELEX and SELEX-like technologies.
- Inclusion of programs for functional site recognition in nucleotide sequences.
- Database installation under SRS and WWW accessibility.
Main Results:
- SELEX_DB provides a curated collection of selected randomized DNA/RNA sequences.
- The database includes functional site recognition programs.
- The first release is available via WWW.
Conclusions:
- SELEX_DB serves as a valuable resource for researchers using SELEX technologies.
- The database facilitates the analysis of functional DNA/RNA sequences.
- Accessibility through WWW enhances data sharing and utilization.
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