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SMARTFlexDB: a paired apo-holo RNA structure database and analysis platform for RNA conformational flexibility and

Shiyu Jiang1,2, Jinhang Wei1,2, Amirhossein Taghavi3

  • 1Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610, United States.

Nucleic Acids Research
|October 26, 2026
PubMed

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RNA Structure01:23

RNA Structure

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RNA Structure

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Ribosome Profiling

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¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

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The axial and equatorial protons in cyclohexane can be distinguished by performing a variable-temperature NMR experiment. In this process, except for one proton, the remaining eleven protons are replaced by deuterium. The deuterium substitution avoids the possible peak splitting caused by the spin-spin coupling between the adjacent protons. The remaining proton flips between the axial and equatorial positions.