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Object-oriented transcription factors database (ooTFD).

D Ghosh1

  • 1Institute for Transcriptional Informatics, PO Box 2556, Pittsburgh, PA 15230, USA. dghosh@ifti.org

Nucleic Acids Research
|December 11, 1999
PubMed
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The object-oriented Transcription Factors Database (ooTFD) captures polypeptide interactions defining transcription factor properties. Recent updates enhance its utility for studying protein-protein interactions in cellular processes.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Transcription factors regulate gene expression through protein interactions.
  • Existing databases may not fully capture the complexity of transcription factor interactions.
  • Understanding these interactions is crucial for deciphering cellular processes.

Purpose of the Study:

  • To introduce ooTFD, an object-oriented successor to TFD.
  • To detail the database's focus on polypeptide interactions defining transcription factors.
  • To highlight recent updates and accessibility of ooTFD.

Main Methods:

  • Object-oriented database design.
  • Information capture of transcription factor binding sites.
  • Documentation of composite relationships and protein-protein interactions.

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Main Results:

  • ooTFD effectively captures intricate details of transcription factor composition and interactions.
  • The database includes information on binding sites and multisubunit protein complexes.
  • Recent additions and modifications have been implemented.

Conclusions:

  • ooTFD provides a comprehensive resource for studying transcription factor interactions.
  • The database facilitates research into protein-protein interactions critical for cellular functions.
  • Updated tools and data are available via the IFTI-MIRAGE website.