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Olfactory receptor database: a sensory chemoreceptor resource.

E Skoufos1, L Marenco, P M Nadkarni

  • 1Center for Medical Informatics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06511, USA. emmanouil.skoufos@yale.edu

Nucleic Acids Research
|December 11, 1999
PubMed
Summary
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The Olfactory Receptor Database (ORDB) now includes diverse chemoreceptors beyond olfactory receptors. This expanded resource enhances understanding of sensory perception and molecular interactions.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Neuroscience

Background:

  • The Olfactory Receptor Database (ORDB) initially focused on olfactory receptors.
  • Sensory chemoreceptors are crucial for detecting environmental cues.
  • A comprehensive resource for chemoreceptor data was lacking.

Purpose of the Study:

  • To expand the Olfactory Receptor Database (ORDB) into a broader chemoreceptor resource.
  • To integrate data on various G-protein-coupled sensory chemoreceptors.
  • To develop a complementary ligand database (OdorDB).

Main Methods:

  • Re-architected the ORDB schema to an Entity-Attribute-Value with Classes and Relationships (EAV/CR) model.
  • Integrated data for six classes of sensory chemoreceptors: olfactory receptor-like proteins, vomeronasal receptors, insect olfactory receptors, worm chemoreceptors, taste papilla receptors, and fungal pheromone receptors.

Related Experiment Videos

  • Developed the OdorDB to store information on receptor ligands.

    • Main Results:

    • The ORDB now encompasses a wider range of chemoreceptor types.
    • The new EAV/CR schema enhances interoperability with other databases.
    • The OdorDB provides a pilot-mode public resource for odorant ligands.
    • Interactive tools for phylogenetic analysis and sequence alignment are now available.

    Conclusions:

    • The expanded ORDB offers a unified platform for studying diverse chemoreceptors.
    • Improved data interoperability facilitates comprehensive research from ligand binding to neuronal activity.
    • The integrated resources support advanced research in sensory biology and neuroscience.