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[Acute cholestatic hepatitis induced by dextromethorphan].

C de la Serna Higuera1, S J Rodríguez Gómez, A Pérez Villoria

  • 1Unidad de Digestivo, Servicio de Medicina Interna, Hospital Virgen de la Concha, Zamora.

Gastroenterologia Y Hepatologia
|December 11, 1999
PubMed
Summary

Dextromethorphan, a cough medicine, can cause liver injury (cholestatic syndrome) in some individuals. Stopping the medication led to rapid recovery and normalized liver function markers.

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Area of Science:

  • Pharmacology
  • Hepatology
  • Clinical Toxicology

Background:

  • Dextromethorphan is a widely used antitussive agent.
  • Flu-like syndromes are common indications for symptomatic treatment.
  • Adverse drug reactions require careful monitoring and reporting.

Observation:

  • A 68-year-old female presented with a flu-like syndrome.
  • She was treated with dextromethorphan.
  • Five days later, a cholestatic syndrome developed without fever or abdominal pain.

Findings:

  • Discontinuation of dextromethorphan resulted in rapid clinical improvement.
  • Biochemical markers of cholestasis decreased following drug withdrawal.
  • Complete normalization of liver function tests was observed within two months.

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Implications:

  • Dextromethorphan can induce cholestatic liver injury.
  • Early recognition and withdrawal of the offending agent are crucial for recovery.
  • Understanding the pathogenic mechanisms of drug-induced cholestasis is important for patient safety.