A novel percutaneous barrier device that permits safe subcutaneous access

Area of Science:

• Biomaterials Engineering
• Regenerative Medicine
• Medical Device Design

Background:

• Long-term subcutaneous access is crucial for artificial organs and disease treatment.
• Skin downgrowth and infection remain significant challenges with current devices.
• A need exists for improved percutaneous devices minimizing complications.

Purpose of the Study:

• To develop and evaluate a novel percutaneous device for stable subcutaneous access.
• To create a biologic boundary that integrates with surrounding connective tissue.
• To minimize risks of skin downgrowth and infection.

Main Methods:

• A percutaneous device with a mesh collar featuring millimeter-sized pores was designed.
• The device facilitates connective tissue ingrowth and capillary formation.
• A biosealed junction was formed between the device and surrounding tissue.

Main Results:

• Connective tissue successfully grew through the mesh pores, creating a strong bond.
• Adequate blood supply was ensured via capillary growth.
• The device demonstrated immediate functionality post-implantation in rabbit models.
• No signs of tissue injury or inflammation were observed over 8 months.

Conclusions:

• The novel percutaneous device establishes a stable and effective connection to internal organs.
• It successfully prevents bioboundary damage, skin downgrowth, and tissue infection.
• This device offers a promising solution for long-term subcutaneous access.