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Related Experiment Videos

An empirical model on extractive lactic acid bioconversion.

A Srivastava1, R Yunus, P K Roychoudhury

  • 1Centre for Process Biotechnology, Department of Biotechnology, The Technical University of Denmark, Lyngby.

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
|December 14, 1999
PubMed
Summary

This study introduces a mathematical model for extractive lactic acid bioconversion using ion-exchange resin. The model minimizes product inhibition, leading to higher productivity and reduced substrate waste in industrial fermentation.

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Area of Science:

  • Biotechnology and Biochemical Engineering
  • Fermentation Technology
  • Process Modeling and Simulation

Background:

  • Commercial lactic acid production faces challenges in purification and cost-competitiveness compared to chemical synthesis.
  • High cell density in fermenters is crucial for minimizing investment costs, but is often limited by product inhibition.
  • Extractive bioconversion offers a potential solution for commercially viable lactic acid production.

Purpose of the Study:

  • To develop an empirical mathematical model for extractive lactic acid bioconversion using an ion-exchange resin process.
  • To analyze and improve the kinetics of microbial growth and product formation under product inhibition.
  • To validate the model's effectiveness in enhancing process productivity and efficiency.

Main Methods:

Related Experiment Videos

  • Development of an empirical mathematical model based on generalized Monod's growth and Leudeking and Piret equations.
  • Incorporation of end-product (lactic acid) inhibition effects on growth and production kinetics.
  • Utilized non-linear regression for kinetic parameter evaluation and the fourth-order Runge Kutta method for solving differential equations.

Main Results:

  • The developed model successfully simulated the extractive batch recycle bioconversion process.
  • The extractive technique significantly minimized the inhibitory effect of lactic acid on process kinetics.
  • Achieved higher productivity and reduced substrate utilization for cell maintenance compared to conventional methods.

Conclusions:

  • The empirical mathematical model provides a valuable tool for optimizing extractive lactic acid bioconversion.
  • This approach enhances the commercial viability of fermentation-based lactic acid production.
  • The model's validity was statistically confirmed using an F-test at a significance level of alpha = 0.05.