Effect of aging on the dissolution stability of glibenclamide/beta-cyclodextrin complex
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Updated: Oct 18, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
1Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Abstract:
The effect of aging on the physicochemical stability of glibenclamide (GB)/beta-cyclodextrin (CD) systems and tablets made with CD-complexed GB was studied. Infrared (IR) spectrometry and X-ray diffraction analyses showed that the properties of the products were unaffected even after a storage period of 4 years, except that the crystallinity of GB/CD physical mixture was decreased with aging. The dissolution rate of the kneaded mixture, inclusion complex, and tablets made with the inclusion complex were unaffected on storage for 4 years. Thus, the age-related dissolution problems of GB can be overcome by utilizing the GB/CD complex in the tablet dosage form.
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