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Meta-analysis by combining p-values: simulated linkage studies
R Guerra1, C J Etzel, D R Goldstein
1Department of Statistical Science, Southern Methodist University, Dallas, TX 75275, USA.
Abstract:
Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were consistently found by pooling raw data. In the absence of further information, combining p-values can provide an overall, but limited, assessment of different linkage studies. However, meta-analysis would be better viewed as a preliminary step toward the goal of analyzing the pooled raw data.
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