[Comparative study of Hashimoto thyroiditis and "focal thyroiditis"]
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Updated: Oct 18, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
M A Pal'tsev1, V B Zolotarevskiĭ, A A Ivanov
1I. M. Sechenov Moscow Medical Academy, Moscow.
Abstract:
As shown by a semiquantitative analysis of histological changes in the thyroid tissue, there is a correlation between some characteristic features of autoimmune thyroiditis (Hashimoto's thyroiditis). Formation of lymphoid nodules in the thyroid in autoimmune thyroiditis was followed up and its three stages were distinguished. Autoimmune thyroiditis has three degrees of activity by diffuse lymphoid-plasmocytic infiltration, thyroid tissue destruction and lymphoid nodules formation. Differences between autoimmune thyroiditis and focal thyroiditis are revealed. The above differences include spread and cellular composition, content of the lymphoid-plasmocytic infiltrate, the degree of the destructive changes, B-cell hyperplasia, expression of CD-4 on T-helpers and CD-19 on B-lymphocytes, cytological picture. These differences allow differential diagnosis between these diseases.
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