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Do pipecuronium and rocuronium affect human bronchial smooth muscle?
1Servizio di Anestesia e Rianimazione, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. rehder.kai@Mayo.edu
Anesthesiology
|December 22, 1999
Summary
Pipecuronium bromide, but not rocuronium bromide, inhibits stimulated M2 muscarinic receptors in human airways at clinical concentrations. This study clarifies muscle relaxant interactions with airway receptors.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Anesthesiology
Background:
- Muscle relaxants interact with nicotinic and muscarinic receptors.
- The effects of muscle relaxants on human airway muscarinic receptors are not fully understood.
Purpose of the Study:
- To investigate the effects of pipecuronium bromide and rocuronium bromide on prejunctional and postjunctional muscarinic receptors in human airways.
Main Methods:
- Isolated human bronchial rings were used to study contractile responses.
- Muscarinic receptor function was assessed via electric field stimulation and acetylcholine concentration-response curves.
- The impact of pipecuronium bromide and rocuronium bromide on stimulated and non-stimulated M2 and M3 receptors was evaluated.
Main Results:
- Pipecuronium bromide inhibited pilocarpine-stimulated prejunctional M2 muscarinic receptors.
- Rocuronium bromide did not inhibit stimulated prejunctional M2 muscarinic receptors.
- Neither muscle relaxant significantly affected non-stimulated M2 or postjunctional M3 muscarinic receptors.
Conclusions:
- Pipecuronium bromide demonstrated inhibitory effects on stimulated prejunctional M2 muscarinic receptors at clinically relevant concentrations.
- These findings contribute to understanding the nuanced interactions between muscle relaxants and airway receptors.