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Related Experiment Videos

Stinging and rosacea.

S B Lonne-Rahm1, T Fischer, M Berg

  • 1Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

Acta Dermato-Venereologica
|December 22, 1999
PubMed
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Rosacea patients exhibit increased skin sensitivity, reacting more frequently to a 5% lactic acid test than healthy individuals. This supports vascular sensitivity as a key factor in rosacea development.

Area of Science:

  • Dermatology
  • Cutaneous Biology
  • Clinical Research

Background:

  • Rosacea is a common inflammatory skin condition characterized by facial redness, papules, pustules, and telangiectasias.
  • The pathophysiology of rosacea is not fully understood but is thought to involve neurovascular dysregulation and heightened skin sensitivity.
  • Sensitive skin, often manifesting as stinging or burning sensations, is frequently reported by individuals with rosacea.

Purpose of the Study:

  • To investigate objective skin sensitivity in patients with rosacea compared to healthy controls.
  • To explore potential differences in skin sensitivity between subtypes of rosacea (papulopustular and erythematotelangiectatic).
  • To evaluate the role of vascular sensitivity in the etiology of rosacea.

Main Methods:

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  • A single-blind study involving 32 rosacea patients (25 papulopustular, 7 erythematotelangiectatic) and 32 healthy controls.
  • Application of a 5% lactic acid solution and pure water to the cheeks of all participants.
  • Objective assessment of 'stinger' reactions, indicating positive sensitivity response.

    • Main Results:

    • A significantly higher proportion of rosacea patients (24/32) reacted as 'stingers' compared to healthy controls (6/32) (p<0.001).
    • All patients with erythematotelangiectatic rosacea (7/7) were stingers, while 17/25 papulopustular rosacea patients reacted.
    • No statistically significant difference in stinging reactions was found between rosacea subtypes (n.s.).

    Conclusions:

    • The study supports the hypothesis that impaired response to stimuli, likely due to vascular sensitivity, is a central mechanism in rosacea etiology.
    • Objective testing confirms heightened sensory responses in rosacea patients, correlating with subjective sensitive skin experiences.
    • Further research is needed to determine the precise correlation between sensitive blood vessels and sensitive skin in rosacea.