Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmunity and diabetes.

A Kukreja1, N K Maclaren

  • 1Department of Pediatrics, Weill Medical College, Cornell University, New York, New York 10021, USA.

The Journal of Clinical Endocrinology and Metabolism
|December 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First case report of paragonimiasis in a Malaysian man.

Tropical biomedicine·2021
Same author

Efficacy of C.E.R.A. in Routine Clinical Practice for Correction of Anaemia and Maintenance of the Haemoglobin Levels in CKD Patients not on Dialysis.

The Journal of the Association of Physicians of India·2017
Same author

Introduction.

Pediatric annals·2014
Same author

Diagnosis and treatment of diabetic ketoacidosis.

Pediatric annals·2014
Same author

Physiology of diabetes.

Pediatric annals·2014
Same author

Multiple autoantibodies as predictors of Type 1 diabetes in a general population.

Diabetologia·2003
Same journal

Continuous glucose monitoring-derived time in range is associated with changes in arterial stiffness in type 2 diabetes.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Association of the Primary Aldosteronism Severity Classification with Lateralization and Treatment Outcomes.

The Journal of clinical endocrinology and metabolism·2026
Same journal

From Premature Adrenarche to Adult Metabolic Risk and Hyperandrogenism: A Systematic Review and Meta-Analysis.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Open-Label 9-Year Follow-Up Extension Phase 2 Study of Once-Weekly Somatrogon in Children With Growth Hormone Deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same journal

Correction to: "CAHQL: A Patient-Reported Outcome Instrument to Assess Health-Related Quality of Life in Congenital Adrenal Hyperplasia".

The Journal of clinical endocrinology and metabolism·2026
Same journal

Approach to Personalizing the Treatment of Osteoporosis.

The Journal of clinical endocrinology and metabolism·2026
See all related articles

Type 1 diabetes is increasingly affecting younger children due to environmental factors and genetic predispositions. Research highlights immune system defects and identifies B lymphocytes as key antigen-presenting cells, offering hope for future prevention strategies like diabetes vaccines.

Area of Science:

  • Immunology and Endocrinology
  • Autoimmune Diseases
  • Metabolic Disorders

Background:

  • Immune-mediated (type 1) diabetes incidence is rising in Western countries, affecting younger populations.
  • Complex genetic factors combined with environmental triggers are implicated in the disease's increasing prevalence.
  • Defects in immunological tolerance to self-antigens are central to the development of type 1 diabetes.

Purpose of the Study:

  • To explore the changing epidemiology of type 1 diabetes.
  • To investigate the immunological defects contributing to the disease.
  • To identify potential targets for disease prediction and prevention.

Main Methods:

  • Analysis of epidemiological trends in type 1 diabetes incidence.
  • Examination of immune cell function, including natural killer T cells and T cells.

Related Experiment Videos

  • Investigation of antigen-presenting cells, specifically B lymphocytes, in autoimmune processes.
  • Identification and characterization of beta cell autoantigens.

    • Main Results:

    • Natural killer T cells appear deficient in both human patients and animal models.
    • Regulatory T cell function seems compromised in individuals with type 1 diabetes.
    • B lymphocytes are identified as crucial antigen-presenting cells in the autoimmune pathogenesis.
    • Understanding beta cell autoantigens has improved disease prediction capabilities.

    Conclusions:

    • The rising incidence of type 1 diabetes suggests environmental factors interacting with genetic susceptibility.
    • Immune system dysregulation, including defects in T cells and the role of B cells, is critical.
    • The long prodromal phase, detectable by autoantibodies, presents opportunities for early intervention and prevention, potentially through antigen-based therapies or diabetes vaccines.