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Low-grade endometrial stromal sarcoma with cardiovascular involvement--a report of three cases
T Tabata1, N Takeshima, Y Hirai
1Department of Gynecology, Cancer Institute Hospital, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo, 170-8455, Japan.
Insights
Low-grade endometrial stromal sarcoma can extend to large vessels, including the heart. This rare cardiovascular involvement necessitates vigilance throughout patient care.
Area of Science:
- Gynecologic Oncology
- Cardiovascular Pathology
- Medical Imaging
Background:
- Low-grade endometrial stromal sarcoma (LGESS) frequently shows vascular space involvement in surgical specimens.
- Cardiovascular extension is considered rare in LGESS, unlike intravenous leiomyomatosis.
Observation:
- Three cases of LGESS with cardiovascular involvement are presented.
- Recurrent tumors were identified via imaging studies.
- Two cases involved the inferior vena cava; one involved the left ventricle.
Findings:
- Demonstrates rare instances of LGESS extending into major cardiovascular structures.
- Highlights the potential for LGESS to infiltrate the inferior vena cava and heart chambers.
Implications:
- Clinicians should consider the possibility of cardiovascular invasion in LGESS patients.
- Enhanced surveillance for cardiovascular complications may be warranted in LGESS management.
- This finding expands the understanding of LGESS metastatic potential.
Background:
In low-grade endometrial stromal sarcoma, it has been reported that vascular space involvement in surgical specimens is found in over 50% of patients. However, in contrast to intravenous leiomyomatosis, it has been thought that further tumor extension to large vessels is rarely observed.
Cases:
We present three cases of low-grade endometrial stromal sarcoma with cardiovascular involvement by recurrent tumors observed on imaging studies. Two cases demonstrated tumor infiltration inside the inferior vena cava while the other case showed tumor growth in the left ventricle.
Conclusion:
This report suggests that attention should be paid to the possibility of cardiovascular invasion during the entire course of this disease.