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Updated: Aug 9, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
Published on: September 20, 2012
Complete primary structure of the chicken alpha1(V) collagen chain
M K Gordon1, J K Marchant, J W Foley
1Department of Pharmacology and Toxicology, Rutgers College of Pharmacy, EOHSI Rutgers University, Piscataway, NJ 08854, USA.
Researchers have sequenced chicken alpha1(V) collagen, providing the complete translated sequence. This sequence is compared to related collagen chains in the type V/XI family.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Collagen V is a fibril-associated collagen involved in regulating collagen fibril diameter.
- Type V/XI collagen family members share structural similarities and play crucial roles in tissue development and organization.
Purpose of the Study:
- To present the entire translated amino acid sequence of chicken alpha1(V) collagen.
- To compare specific regions of chicken alpha1(V) collagen with other members of the type V/XI collagen family.
Main Methods:
- Cloning of chicken alpha1(V) collagen cDNAs using various established molecular biology techniques.
- Bioinformatic analysis to determine the complete translated polypeptide sequence.
- Sequence alignment and comparison of selected regions with homologous collagen chains.
Main Results:
- The complete translated amino acid sequence of chicken alpha1(V) collagen was successfully determined.
- Comparative analysis revealed conserved and divergent regions within the type V/XI collagen family.
- Identification of potential functional domains based on sequence homology.
Conclusions:
- The full sequence of chicken alpha1(V) collagen provides a valuable resource for understanding collagen V structure-function relationships.
- Comparative analysis deepens the understanding of evolutionary relationships and functional diversification within the type V/XI collagen family.
- This data can inform future studies on collagen V in development, disease, and tissue engineering.
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