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Mumps interstitial nephritis: a case report
N Kabakuş1, H Aydinoğlu, S A Bakkaloğlu
1Department of Pediatrics Neurology, Ankara University Faculty of Medicine, Ankara, Turkey.
Abstract:
Mumps is still a common childhood disease in rural areas where mumps vaccination is not widespread. A 14-year-old girl with fatal interstitial nephritis as a complication of mumps is reported. The patient had not been vaccinated with mumps vaccine and had contracted mumps during a village epidemic. The illness began with parotitis, and renal insufficiency developed within a week. The patient's renal function rapidly deteriorated and the outcome was fatal. The postmortem renal necropsy sample demonstrated interstitial mononuclear cell infiltration, edema, and focal tubular epithelial cell damage, confirming the clinical diagnosis. In developing countries routine mumps vaccination may help to prevent possible fatal complications of mumps. Furthermore, patients with mumps, especially complicated cases, should be followed closely.
Insights
Mumps can cause fatal kidney complications, even in children, particularly in unvaccinated populations. This case highlights the critical need for mumps vaccination and close patient monitoring to prevent severe outcomes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Nephrology
Background:
- Mumps remains prevalent in unvaccinated rural communities, posing risks for serious complications.
- Mumps vaccination coverage is crucial for preventing widespread outbreaks and associated severe illnesses.
Observation:
- A 14-year-old unvaccinated girl contracted mumps during a village epidemic.
- She developed parotitis followed by rapid renal insufficiency within a week.
Findings:
- The patient experienced fatal interstitial nephritis as a complication of mumps.
- Postmortem examination revealed characteristic renal pathology, including interstitial inflammation and tubular damage.
Implications:
- Routine mumps vaccination in developing countries is essential to prevent fatal complications.
- Enhanced clinical surveillance is necessary for mumps patients, especially those with severe or unusual presentations.